Endocrine Abstracts

Resistance to thyroid hormone is a rare genetic disorder which is usually inherited in an autosomal dominant manner. In this disorder, tissues become resistant to thyroid hormones due to the mutations in thyroid hormone receptor beta gene resulting in compensatory rise in hormone levels. Patients are largely asymptomatic apart from goitre, though some can develop symptoms. Estimated rate of occurrence is in the region of 1 in 40 000 live births.We descri...

Introduction: Immune-checkpoint inhibitors are used in patients with advanced cancers. They are associated with a wide array of side effects known as immune-related adverse events (irAEs). These can affect skin, gastrointestinal tract, multiple endocrine glands, liver and other systems. We report a 69-year-old male with a past medical history of Chronic Obstructive Pulmonary Disease and Lung cancer who was referred by the oncology team with a clinical and biochemical picture o...